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Low Dose Naltrexone (LDN) / Ketamine

Naltrexone is a drug that treats opioid addiction and heroin. Doctors had found that a significantly lower dose of naltrexone (approximately 1/10th of the typical treatment dose) has more benefits for patients such as relieving pain and inflammation, being very low cost and having minimal side effects etc.

How does it work and how to use:

When a patient takes Low Dose Naltrexone (LDN) before bed each night, it is believed that it generates a short-term reserve of endorphins which then regulates the vital elements of the immune system. This leads to an increase in enkephalin and endorphin creation, as well as upsurge of opioid receptor sensitivity and opioid receptor production. Healthy helpers who have used the medication in this manner, have observed their levels of beta-endorphins circling in the blood increased in the subsequent days.
An animal research was also organized by I. Zagon, PHD. He along with his colleague observed a marked growth in metenkephalin levels there as well. Such higher levels will normally go on for about 18-20 hours. Treatment doses usually start in the range of 0.5 to 1.5 mg. Once you start taking the dosage on a nightly basis, it is repeatedly brought up to 4.5 mg.
Low Dose Naltrexone is advised to take between 9 pm and 3 am due to the rhythm of the body’s creation of master hormones. Most patients take this drug before going to bed.

  • For Chronic Fatigue Syndrome, Fibromyalgia, or Hashimoto's Thyroiditis, the beginning dosage is normally 0.5 mg every week until the daily dosage of 4.5 mg is achieved.
  • For autoimmune diseases, patients generally start with 1 mg doses and then increase to 4.5 mg over four weeks.
  • Those with Multiple Sclerosis who are dealing with muscle spasms are advised to start with 3 mg per day and to maintain that dosage.
  • Those with hyperthyroidism, Hashimoto's Thyroiditis, and those who are taking thyroid hormone replacement medication and Low Dose Naltrexone should pay attention to the warnings below:
    • Patients suffering from cancer who are using Low Dose Naltrexone can take similar doses, but these must be avoided the weeks before or after chemotherapy.
    • This does not apply daily treatments for prostate cancer and tamoxifen. The range of medicinal dosages for Low Dose Naltrexone (LDN) is between 1.5 to 4.5 mg every night. Quantities below this level will perhaps be futile. Quantities of more than this amount will possibly stop the endorphins for too long of a period and the drug will not be as efficient.
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